Toxics Watch was founded in 1986 as "a needed and timely response to the growing use of toxic chemicals in our province."
Toxics Watch's first project was to sponsor and co-ordinate the first Toxic Round Up in the City of Edmonton. Subsequently, the City took over the program, and Toxics Watch played an active role in the annual event until 1994, when the first Eco Station was opened and the Round Up discontinued.
Toxics Watch took a lead opposition role in the NRCB hearings looking into the expansion of the Swan Hills hazardous waste facility, and the subsequent decision to allow the importation of hazardous wastes from out of province.
In recent years, Toxics Watch's attention has swung towards Alberta's energy industry, especially oil sands development in the Wood Buffalo region, and coal-fired electricity generation near Lake Wabumun.